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Testing to individualize your approach for invasive fungal infections

When you suspect your immunocompromised or transplant patient has an invasive fungal infection (IFI), one day can be the difference between life and death.

With a robust fungal menu, differential testing, faster result turnaround time and diagnostics to monitor drug levels, Eurofins Viracor can help you better support your patients' continuum of care — from the onset of symptoms to managing dosage.

When timing is critical, can you afford not to know?

Risks of Treatment Delay

Treat IFIs Faster, Reduce Mortality

Managing fungal infections in immunocompromised individuals can be challenging due to a lack of specific symptoms and increased drug resistance. A rapid and accurate diagnosis is key in reducing the risk of mortality due to delayed treatment.1,2 

Utilizing Therapeutic Drug Monitoring

Manage Drug Levels, Keep Patients in the Therapeutic Range

For high-risk IFI patients, early individualized treatment is critical. Antifungal therapeutic drug monitoring is necessary for managing efficacy and safety.

The below chart shows the relationship between voriconazole dosage and blood levels.
In this study, up to 35% of patients samples were outside the therapeutic range.3

 

Diagnostics for Fungal Patients' Complete Continuum of Care

Test Name

Test Code

Turnaround Time

Fungal Plus PCR Profile I
Aspergillus • Nocardia • Mucorales

PFL8005

Same day (within 12 - 24 hours from receipt of specimen), Monday through Friday.

Fungal Plus PCR Profile II
Aspergillus • Nocardia • Mucorales • Pneumocystis jiroveci

PFL8006

Fungitell® β-D-Glucan

1700

Fungitell® β-D-Glucan with Reflex to Titer

351700

Same day (within 8-12 hours from receipt of specimen), Monday through Saturday. Additional 8-24 hours when reflex testing is required.

Aspergillus Real-time PCR Panel

8900

Same day (within 12 - 24 hours from receipt of specimen), Monday through Friday.

OMEGA Coccidioides Antibody EIA

3400

3 days from sample receipt. Testing performed at VRL-Eurofins.

Galactomannan EIA

1600

Same day (within 8 - 12 hours from receipt of specimen), Monday through Saturday.

Histoplasma Galactomannan EIA

30881 / 30882

Same day (within 8 - 18 hours from receipt of specimen), Monday through Saturday.

Mucorales Real-time PCR

3200

Same day (within 12 - 24 hours from receipt of specimen), Monday through Friday.

Nocardia Real-time PCR

6800

Same day (within 8-12 hours from receipt of specimen), Monday through Saturday.

Pneumocystis jiroveci Quantitative Real-time PCR

2000

Isavuconazole (CRESEMBA®) LC-MS/MS

4900

Itraconazole LC-MS/MS

2800

Posaconazole LC-MS/MS

4200

Voriconazole LC-MS/MS

3300

References

1 Assoc of Cape Cod, Fungitell Assay Instructions for Use. 2011 (Feb) Garey et al, Clin Infect Dis. 2006; 43:25-31. Karageorgopoulos et al. Clin Inf Dis. 2011; 52:750-770

2 Luong ML et al. Clin Inf Dis. 2012; 52 (10):1218-1226. Nguyen ML, Wissel MC et al. Clin Inf Dis. 2012; 54:1240-1248.

3 Andres Pascual, Thierry Calandra, Saskia Bolay, Thierry Buclin, Jacques Bille, and Oscar Marchetti, Voriconazole Therapeutic Drug Monitoring in Patients with Invasive Mycoses Improves Efficacy and Safety Outcomes, Clinical Infectious Diseases, 2008:46(2);204 by permission of Infectious Diseases Society of America.

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