MAGIC Composite Response for aGVHD
Viracor’s MAGIC Composite Response for aGVHD test can aid in prediction of some of the most severe forms of acute graft versus host disease (aGVHD) and non-relapse mortality (NRM) before disease progression becomes serious. The aGVHD Symptomatic Onset Algorithm reports on ST2 and Regenerating islet-derived 3-alpha (REG3α) biomarkers, utilizing them to provide a clinically validated cutoff value. The MAGIC Composite Response for aGVHDe assay uses both clinical and biomarker data which has enlarged the low-risk group and has been show to most accurately predict outcomes along with response to therapy. This assay should be ordered after the patient displays symptoms of aGVHD post bone marrow, stem cell, or other kinds of hematopoietic cell transplant (HCT).
The Manhattan risk score is based only on the clinical information provided and is an assessment of risk for unfavorable outcomes. The MAGIC Composite Response for aGVHD score combines the Manhattan risk score and the aGVHD Symptomatic Onset Algorithm result to yield a score of 0, 1, 2 or 3 (0 being most favorable). Overall response rate is defined by complete or partial response at day 28 after systemic treatment. For more information see: Blood 2024, 144(9):1010-1021, PMID 38968143.
Information of the symptomology of the patient is required to determine the Manhattan Risk Score. Patient symptoms related to Skin, Liver, Upper GI, and Lower GI are graded on their presentation and severity to determine the Manhattan Risk Score in conjunction with the MAGIC Algorithm Probability (MAP) to guide Acute GvHD Therapy.
About the Test
When the Manhattan score is combined with the MAGIC aGVHD biomarkers at symptomatic onset, the composite result demonstrates: An improved prognostic performance (6-month non-relapse mortality [NRM] and the ability to predict response to treatment at day 28.
This provides improved opportunities for personalized treatment strategies, potentially reducing the reliance on high-dose systemic immunosuppressive therapies that often come with significant adverse effects.
Same day (within 24 hours of receipt of specimen)
| Specimen Type | Test Code | CPT Code | NY Approved | Volume | Assay Range | Special Instructions |
|---|---|---|---|---|---|---|
| Serum | 403724P | 83006 ST2 and 83520 Reg3 | Yes | 0.5 mL (min. 0.5mL) |
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Ship Monday through Friday. Friday shipments must be labeled for Saturday delivery. All specimens must be labeled with patient's name and collection date. A Eurofins Viracor test requisition form must accompany each specimen. Multiple tests can be run on one specimen. Ship specimens FedEx Priority Overnight® to: Eurofins Viracor, 18000 W 99th St., Ste, #10, Lenexa, KS 66219.
Causes for RejectionSample maintained outside of validated stability conditions
Specimens are approved for testing in New York only when indicated in the Specimen Information field above.
The CPT codes provided are based on Eurofins Viracor’s interpretation of the American Medical Association's Current Procedural Terminology (CPT) codes and are provided for informational purposes only. CPT coding is the sole responsibility of the billing party. Questions regarding coding should be addressed to your local Medicare carrier. Eurofins Viracor assumes no responsibility for billing errors due to reliance on the CPT codes illustrated in this material.
References
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Yu Akahoshi,MD,PhD, Nikolaos Spyrou,MD, Daniela Weber,MD, et al. The Mount Sina iAcute Gvhd International Consortium (MAGIC) Model :An Integrated Clinical and Biomarker Grading System for Acute Graft-Versus-Host Disease(GVHD). Abstracts/Transplantation and Cellular Therapy 302S(2024)S48-S53.