33611 - IL-18 (plasma)
Cytokines and chemokines play critical roles in regulating innate and adaptive immune responses. Quantitative assessment of immune signaling biomarkers can provide insight into inflammatory pathways associated with immune activation.
About Test
Interleukin-18 (IL-18) (also known as Interferon-gamma Inducing Factor) is a pro-inflammatory cytokine and member of the IL-1 superfamily that serves as a potent inducer of IFN-γ production from T cells and NK cells, bridging innate and adaptive immune responses. IL-18 is constitutively expressed as an inactive precursor in nearly all cell types, and its activation and secretion is regulated through inflammasome processing. Free IL-18 (not bound by its endogenous inhibitor, IL-18 binding protein/IL-18BP) represents the biologically active form.
ProcedureQuantitative Multiplex Fluorescence Immunoassay. This test was developed and its performance characteristics were determined by Eurofins Viracor. This test has not been cleared or approved for diagnostic use by the U.S. Food and Drug Administration.
Specificity<2% off-target recovery when tested using samples individually spiked with 1200, 760, & 400 pg/mL CXCL9, or 1400, 900, & 500 pg/mL CXCL10
24 hours from receipt of specimen. To meet the 24-hour turnaround time, test orders will need to be received at the lab by 11am CST. Monday - Saturday.
| Specimen Type | Test Code | CPT Code | NY Approved | Volume | Assay Range | Special Instructions |
|---|---|---|---|---|---|---|
| plasma | 33611 | 83520 | No | 1 mL (min. 200 uL) |
245 - 59510 pg/mL |
|
The reference range for a healthy population is less than 245 pg/mL The reference range for this assay was determined from a population of healthy adults.
Specimens are approved for testing in New York only when indicated in the Specimen Information field above. The CPT codes provided are based on Eurofins Viracor’s interpretation of the American Medical Association's Current Procedural Terminology (CPT) codes and are provided for informational purposes only. CPT coding is the sole responsibility of the billing party. Questions regarding coding should be addressed to your local Medicare carrier. Eurofins Viracor assumes no responsibility for billing errors due to reliance on the CPT codes illustrated in this material.
References- Cecrdlova E, et al. Insights into IL-1 family cytokines in kidney allograft transplantation: IL-18BP and free IL-18 as emerging biomarkers. Cytokine. 2024;180:156660. https://doi.org/10.1016/j.cyto.2024.156660
- Liu C, et al. Role of IL-18 in transplant biology. Eur Cytokine Netw. 2018;29(2):48-51. https://doi.org/10.1684/ecn.2018.0410
- Basta-Jovanovic G, et al. Acute Renal Failure — A Serious Complication in Patients After Kidney Transplantation. Curr Med Chem. 2016;23(19):2012-7. https://doi.org/10.2174/092986732319160719192019
- Reese PP, et al. Deceased-Donor Acute Kidney Injury and Acute Rejection in Kidney Transplant Recipients. Am J Kidney Dis. 2022;81(2):222-231. https://doi.org/10.1053/j.ajkd.2022.08.011
- Orsatti L, et al. Kynurenine pathway activation in fibrosing cGVHD. Cell Rep Med. 2021;2(10):100409. https://doi.org/10.1016/j.xcrm.2021.100409
- Kim SC, et al. Urine proteomics in kidney transplantation. Transplant Rev. 2014;28(1):15-20. https://doi.org/10.1016/j.trre.2013.10.004