Mannan Binding Lectin (MBL)
Mannan-binding lectin (MBL) is an acute-phase, carbohydrate-binding serum protein secreted by the liver that plays a central role in the innate immune system. Structurally MBL is a C1q-like molecule that in association with MBL associated serine proteases (MASPs) binds to surface carbohydrates on bacteria, fungi, viruses and protozoa making them accessible for phagocytosis through MBL receptors or by activating the complement cascade via the recently elucidated MBL or lectin pathway.
ProcedureEnzyme Immunoassay. The test uses a monoclonal antibody against the oligomeric MBL carbohydrate-binding domain for both capture and detection. The specificity of this monoclonal antibody for oligomeric MBL has been previously reported. This test has not been cleared or approved for diagnostic use by the U.S. Food and Drug Administration.
5-7 business days from receipt of specimen
| Specimen Type | Test Code | CPT Code | NY Approved | Volume | Assay Range | Special Instructions |
|---|---|---|---|---|---|---|
| serum | 33 | 86160 | Yes | 1 mL (min. 100 uL) |
The assay range is approximately 50 to 4000. |
|
Specimens are approved for testing in New York only when indicated in the Specimen Information field above.
The CPT codes provided are based on Eurofins Viracor's interpretation of the American Medical Association's Current Procedural Terminology (CPT) codes and are provided for general informational purposes only. CPT coding is the sole responsibility of the billing party. Questions regarding coding should be addressed to your local Medicare carrier. Eurofins Viracor assumes no responsibility for billing errors due to reliance on the CPT codes illustrated in this material.
ReferencesKilpatrick DC. Mannan-binding lectin and its role in innate immunity. Transfus. Med. 2002; 12:335-352.
Garred, P, et al. Mannose-binding lectin deficiency-revisited. Mol. Immunol. 2003; 40:73-84.
Koch, A, et al. Acute respiratory tract infections and mannosebinding lectin insufficiency during early childhood. JAMA 2001; 285:1316-1321.
Winkelstein, JA & Childs, B. Why do some individuals have more infections than others? JAMA 2001 (Editorial); 285:1348-1349.
Steffensen, R, et al. Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific primers. J. Immunol. Methods 2000; 241:33-42.
Ezekowitz, RAB & Hoffman JA, editors. Innate Immunity. Humana Press, 2003.
Valdimarsson, H, et al. Reconstitution of opsonizing activity by infusion of mannan-binding lectin (MBL) to MBL-deficient Humans. Scand. J. Immunol. 1998; 48:116-123.