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Evaluating Cytomegalovirus (CMV) Cell Mediated Immunity Diagnostic Assays

Over the past two decades, cellular immune response to cytomegalovirus (CMV) and other viral pathogens has been an interesting area of research and has now evolved into a clinical application of assays that provide a precise measure of cellular response. Current antiviral preventative strategies have shown improved efficacy, but CMV continues to be one of the more common clinically significant infections in solid organ transplant (SOT) recipients, hematopoietic stem cell transplant (HSCT) recipients, and other immunocompromising conditions like HIV.

CMV Whitepaper

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Immunity Testing: CMV in Lung Transplant Patients

This bi-lateral lung transplant recipient is a 65 year-old male patient who received his lung transplant due to end-stage lung disease secondary to non-CF bronchiectasis. The donor and recipient CMV serostatus is D+/R+. The patient’s initial peri-operative course was complicated by difficult explant, primary graft dysfunction, respiratory failure requiring prolonged mechanical ventilation, renal insufficiency and recurrent infectious concerns, including pseudomonas and stenotrophomonas pneumonias.