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What is TMA?
Thrombotic microangiopathies (TMA) are a category of diseases linked by endothelial injury leading to aggregation of platelets on the damaged endothelium, microvascular thrombosis and organ dysfunction related to microvascular injury.
Transplant-associated thrombotic microangiopathy (TA-TMA) occurs when endothelial injury in the context of allogeneic hematopoietic cell transplantation (allo-HCT) causes microangiopathic hemolytic anemia and platelet consumption, resulting in microvascular thrombosis and fibrin deposition in the microcirculation.
Transplant-associated thrombotic microangiopathy (TA-TMA) is a complication of stem cell transplants that can occur with peripherally mobilized stem cells or bone marrow-derived stem cells.
Contact us to learn more about the TA-TMA assays
33334 - TA-TMA CH50 33335 - TA-TMA sC5b-9 33336 - TA-TMA Eculizumab
Next Day Results for sC5b-9, CH50 and Eculizumab
Get comprehensive results with the fastest turn around time...anywhere.
Eurofins Viracor's TA-TMA testing stands out for its comprehensiveness, offering clinicians a complete assessment of complement pathway regulation and potential deregulation with validated assays for Eculizumab, CH50, and sC5b-9. Our comprehensive approach ensures that clinicians receive detailed results across all three critical areas, empowering them to make informed decisions about patient treatment promptly, thanks to our industry-leading 24 hour turnaround time.
Transplant Associated Thrombotic MicroAngiopathy
How Does TMA Occur?
Transplant-associated thrombotic microangiopathy (TA-TMA) occurs when endothelial injury in the context of allogeneic hematopoietic cell transplantation (allo-HCT) causes microangiopathic hemolytic anemia and platelet consumption, resulting in microvascular thrombosis and fibrin deposition in the microcirculation.
How is it Diagnosed?
CBC & Schistocyte Smear
LDH & Haptoglobin
PT, Aptt & Fibrinogen
DCT
Serum C5b9
Work up for Viral Infections
Urine for Proteinuria
