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Thrombotic microangiopathies (TMA) are a category of diseases linked by endothelial injury leading to aggregation of platelets on the damaged endothelium, microvascular thrombosis and organ dysfunction related to microvascular injury.
Transplant-associated thrombotic microangiopathy (TA-TMA) occurs when endothelial injury in the context of allogeneic hematopoietic cell transplantation (allo-HCT) causes microangiopathic hemolytic anemia and platelet consumption, resulting in microvascular thrombosis and fibrin deposition in the microcirculation.
Transplant-associated thrombotic microangiopathy (TA-TMA) is a complication of stem cell transplants that can occur with peripherally mobilized stem cells or bone marrow-derived stem cells.
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