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Innovations in Immunity

inSIGHT™ T Cell diagnostic delivers a deeper understanding of patients' response to viral antigens

  • Assess current immune response for viral target

  • Confirm if virus specific CD4 and CD8 T Cells are present

  • Evaluate treatment decisions

Learn more about Eurofins Viracor inSIGHT™ for examining T cell response:

It's your job to keep patients safe; our job is to help you do it.

The Advantages of inSIGHT™

With inSIGHT™, you're now armed with the data to help answer critical questions: Is the patient's body producing a T Cell response? Is that response strong enough to make treatment adjustments? Are they ready to discontinue antiviral medication?

For Clinical Staff

  • Reports CD4 and CD8 responses separately
  • Provides numerical values for various reportables
  • Ability for result consultation with scientific liaisons

For Lab Staff

  • Does not require additional staff or training
  • Live cell ambient shippers available
  • Simple blood draw, no extra processing to isolate PBMC

CASE STUDY: Review a bi-lateral lung transplant patient case study to see how they utilized inSIGHT testing to evaluate prophylaxis..

CMV Immunity Testing in a Lung Transplant Recipient

The ability to monitor the presence or absence of virus specific, highly functional T cells will be an important tool, along with monitoring viral load, in managing patients post-transplant as their immune system recovers.
EBV T Cell Immunity Testing Abstract Poster Presentation
Abstract Poster Presentation at The 2022 Tandem Meetings | Transplantation & Cellular Therapy Meetings of ASBMT and CIBMTR:

"Detection of Epstein-Barr Virus Specific Functional T Cells By Flow Cytometry"

The ability to evaluate EBV specific T cell responses post-transplant is currently an unmet need for managing patients at risk of developing post-transplant lymphoproliferative disorder (PTLD). Functional impairment or lack of a T cell response to EBV has been predicted to drive the development of PTLD. Research indicates...

Click here to view the entire poster presentation.

Flebbe-Rehwaldt, L. Detection of Epstein-Barr Virus Specific Functional T Cells by Flow Cytometry. In: The 2022 Tandem Meetings | Transplantation & Cellular Therapy Meetings of ASBMT and CIBMTR; April 23-26; Salt Lake City, UT; Abstract Number 479.

WHITE PAPER

Evaluating Cytomegalovirus Cell Mediated Immunity Diagnostic Assays

T Cell Immunity Testing - Flow Cytometry

How It Works

inSIGHT™ utilizes intracellular cytokine staining analyzed by flow cytometry to measure the strength of T cell responses to viral specific antigens or proteins. It evaluates and reports the activity of CD4 and CD8 T Cell responses separately.

 

Results Reporting

… Unlike ELISpot or QuantiFERONassays, ICS can thus provide both quantitative and qualitative characteristics of CMV-specific T cells.”

Kotton CN, Kumar D, Caliendo AM, et al. International consensus guidelines on the management of cytomegalovirus in solid organ transplantation. Transplantation. Apr 15 2010;89(7):779-95.

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