Innovations in Immunity
Learn more about Eurofins Viracor ExPeCT
ExPeCT anti-CD19 (FMC63) CAR T qPCR will allow you to personalize patient care by directly following the expansion and persistence of CAR-T cell therapy.
Longitudinally monitoring CAR-T expansion / persistence through our qPCR assay gives you real-time data of the CAR-T therapy.
This qPCR is meant to be an adjunctive measure to your current protocol providing further clinical insights into your patients.
personalized patient care
For Clinical Staff
For Lab Staff
These considerations include;
interventional data providing a reliable means of longitudinal monitoring anti-CD19 CAR-T cell expansion and/or persistence
ExPeCT anti-CD19 (FMC63) CAR T
Eurofins Viracor has developed and validated a multiplexed quantitative real-time PCR (qPCR) assay targeting FMC63 for the longitudinal monitoring of CD19-directed CAR T-cell therapy.
Chimeric antigen receptor (CAR) T-cell therapy has transformed hematological cancer treatment, with six therapies now approved by the FDA. Four of these therapies (tisa cel, axi cel, brexu cel, and liso cel) target CD19 using single chain variable fragments (scFvs) derived from the heavy and light chain variable (V H and V L ) regions of the monoclonal antibody FMC63.
The primary objective of this study was to evaluate the ability of FMC63 scFv specific real time PCR (qPCR) to detect and quantify FMC63 DNA in whole blood specimens. This assay is intended for the quantitative detection of FMC63 DNA from CAR T-cells in whole blood specimens for the purpose of monitoring CAR T-cell engraftment, expansion, and persistence in individuals receiving CD19 directed CAR T-cell therapy.
Here we describe the development, validation and performance characteristics of a multiplexed, quantitative qPCR assay targeting FMC63 for the monitoring of CD19 directed CAR T-cell therapy.
For Hematology/Oncology patients the ExPeCT anti-CD19 (FMC63) CAR T assay provides interventional data which may provide information on the expansion and persistence of the genetically modified T-cells used as therapeutic treatment for specific lymphomas and leukemias (Chimeric Antigen Receptor T-cell therapy or CAR T). Eurofins Viracor has developed and validated a multiplexed quantitative real-time PCR (qPCR) assay targeting FMC63 for the longitudinal monitoring of CD19-directed CAR T-cell therapy.